Figure 6 from Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study
Year: 2025
Type: other
Abstract: Prediction of Acetalax and bisacodyl activity based on transcript expression in the TNBC cell lines of the GDSC. A, Schematic of the approach used to generate B and C. B, Prediction of Acetalax activity based on transcript expression. The left panel is correlation. The middle and right panels demonstrate increasing levels of prediction when including additional genes in multivariate analysis (calculated in R). C, Same as B for bisacodyl. For P value determination of the multigene panels, we used our multivariate analysis web tool (https://discover.nci.nih.gov/rsconnect/cellminercdb/) with 10× cross-validation. The drug activity and transcript (microarray) levels referred to in all panels were as measured by GDSC. The circles are cell lines. The red lines are regression lines. act, activity; exp, expression.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4408033741