Figure 1 from Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study
Year: 2025
Type: other
Abstract: TNBC cell line determination and Acetalax and bisacodyl drug characterization. A, Transcript-level scatter plot of estrogen receptor (ESR1, x-axis) vs. progesterone receptor (PGR, y-axis). B, Transcript-level scatter plot of ESR1 (right plot, x-axis) vs. ERBB2 (y-axis). For both A and B, the transcript measurements are from GDSC microarray, the circles are cell lines with red being TNBC and blue the other breast cancer cell lines. For the CDB scatter plot details, “Select Tissues\To include\Breast” was used to limit the cell lines and “Show color”\“Breast Triple negative” to make the triple negatives red. All scatter plots referring to CellMinerCDB will use the same approach with variable selection of cell line subgroups and coloring. C, Density plots of drug activity z-score comparisons in the 22 TNBC cell lines in GDSC of 58 FDA-approved drugs (gray). The mean values for several drugs used clinically for TNBC are included for reference. D, Density plots of drug activity z-score comparisons in the 22 TNBC cell lines in GDSC of Acetalax (red). E, Density plots of drug activity z-score comparisons in the 22 TNBC cell lines in GDSC of bisacodyl (blue). The x-axis for C–E is the drug activities (z-scores). The height of the bars represents the proportion of cells within the defined range of activity that is the density (y-axis). The vertical lines are the means, with two means being shown for the bimodal plots (for the resistant and sensitive groups). F, Principal component analysis of GDSC z-score drug activity for Acetalax and bisacodyl as compared with the FDA-approved drugs for all (GDSC) cell lines. The drug names in purple are currently used for treatment of TNBC. The proportion of variance explained by PC2 is 6%. G, Principal component analysis of GDSC z-score drug activity for Acetalax and bisacodyl as compared with the clinical trial drugs for all (GDSC) cell lines. For both F and G, each circle is a drug. Both plots visualize PC1 (x-axis) vs. PC3 (y-axis). The proportion of variance explained by PC2 is 7.9%. H, Hierarchical clustering of the GDSC FDA-approved drug z-score data for the TNBC cell lines using 1-Pearson correlation distance (x-axis) and average linkage. The 58 drugs plus Acetalax and bisacodyl were included. The y-axis displays the drugs, with colors corresponding to the mechanisms of action (see legend). exp, expression; PCA, principal component analysis; PC, principal component.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4408033980