Prevalence of Culture-Confirmed Pulmonary Tuberculosis Requiring ICU Admission and the Trend in Prevalence Before and During the COVID-19 Pandemic in a Tertiary Academic Medical Center in Kuala Lumpur, Malaysia: A 7-Year Retrospective Cohort Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: There are limited data on pulmonary tuberculosis (PTB) requiring intensive care unit (ICU) admission despite its high mortality rate. The objectives of our study were to determine the prevalence of culture-confirmed PTB requiring ICU admission and the trend in prevalence before and during the COVID-19 pandemic. A retrospective cohort study was conducted on all patients aged ≥18 years with culture-confirmed PTB requiring ICU admission in a Malaysian tertiary academic medical center from 2015 to 2021. The linear-by-linear association test was performed to determine if the trend in prevalence was significant. The overall prevalence of culture-confirmed PTB requiring ICU admission was 8.0% (139/1736). Between 2015 and 2021, the prevalence increased by 5.8% from 1.6% (5/312) to 7.4% (16/215). This study demonstrated an overall low but increasing trend in the prevalence of culture-confirmed PTB requiring ICU admission. Disruption in TB services during the COVID-19 pandemic may have impacted the prevalence trend.
Authors: Nadia Atiya, M. Shahnaz Hasan, Chee Kuan Wong, Azwani Abdullah, Khai Siang Lau, Eu Gene Cheah, Yady Zikry, Ying Xi Ngu, Yik Pheng Teo, Koo Koon Lim
Institutions: University Malaya Medical Centre, University of Malaya
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4408038648