Adverse events after adjuvant radiation therapy for Dupuytren’s disease in the DEPART randomized trial
Year: 2025
Type: article
Abstract: This study reports adverse events after adjuvant radiotherapy in patients with Dupuytren’s disease. Patients for planned limited fasciectomy, collagenase injection or percutaneous needle fasciotomy were enrolled in a randomized controlled trial. Sixty patients were randomized to observation or radiotherapy (30 Gy, 10 fractions) starting within 4 days of the procedure. During a follow-up period of up to 4 years, 114 adverse events were reported. Of 102 (89%) mild adverse events, 45 (44.1%) were attributed to radiotherapy. Of the 12 moderate to severe, three were attributed to radiotherapy. By 6 months, most moderate to severe adverse events had resolved. Between 12 and 36 month follow-ups, the only persistent adverse event attributed to radiotherapy was reduced sweating. In this trial of adjuvant radiotherapy for Dupuytren’s disease, adverse events are generally mild and self-limiting, suggesting that adjuvant radiotherapy is well tolerated. Level of evidence: Level 2, individual RCT
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408039355