Work

High-grade astrocytoma with piloid features: A case report and review of literature

Year: 2025

Type: article

Abstract: Background: High-grade astrocytoma with piloid features (HGAP) is a rare, newly recognized brain tumor, typically seen in middle aged to elderly patients, often associated with neurofibromatosis type 1. Case Description: We report the first documented case of HGAP in Pakistan in a 57-year-old woman with tremors, vertigo, and cerebellar signs. Magnetic resonance imaging showed a cerebellar lesion, and after resection, initial pathology suggested a pilocytic astrocytoma. Molecular testing confirmed HGAP with a CDKN2A/B deletion. Despite treatment, including a second surgery, the disease progressed. Conclusion: This case highlights the diagnostic challenges of HGAP and underscores the importance of advanced molecular testing for accurate diagnosis. Given the poor prognosis and limited treatment options, further research is needed to understand this rare tumor entity better and improve patient outcomes.

Source: Surgical Neurology International

DOI: 10.25259/sni_889_2024

Authors: Zainab Haider Ejaz, Aisha Hassan Memon, Shayan Sirat Maheen Anwar, Shahzad M. Shamim

Institutions: Aga Khan University Hospital, Aga Khan University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4408040086

FWCI: 1.622

Cites: 10

Cited by: 3

Related to: 10