Analytical Method Development and Validation for the Simultaneous Estimation of Fimasartan Potassium Trihydrate and Cilnidipine in Synthetic Mixture by Hplc Method for the Treatment of Hypertension
Year: 2024
Type: article
Abstract: This study aimed to develop and validate an analytical method for the simultaneousestimation of Fimasartan Potassium Trihydrate and Cilnidipine in a synthetic mixture usingthe HPLC method for the treatment of hypertension. A specific, accurate, precise, robust, andcost-effective HPLC method was developed and validated for the quantitative analysis ofFimasartan Potassium Trihydrate and Cilnidipine in a fixed-dose combination. The isocraticelution was performed using a Kromasil C18 column (250 mm × 4.6 mm ID, 5 μm) at 40°C.The mobile phase consisted of Methanol: 0.1% OPA in water (80:20% v/v) at a flow rate of1.0 mL/min. The injection volume was 20 μL, and UV detection was carried out at 223 nmwith a total run time of 12 minutes. Fimasartan Potassium Trihydrate and Cilnidipine wereeluted at retention times of 3.57 min and 7.99 min, respectively.
Source: Cuestiones de Fisioterapia
DOI: 10.48047/g42py576
Authors: Kunal Borse, Chetan Darade, Chandrashekhar Patil, Prabha Bhong, Deepak Somavanshi, Kajal Pansare, Ganesh Sonawane
Institution: Marathwada Mitra Mandal's College of Pharmacy
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4408040114