Work

Rest and rinse: sleeping rhythms drive brain detox

Year: 2025

Type: article

Abstract: Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

Source: Trends in Immunology

DOI: 10.1016/j.it.2025.02.007

Authors: Leon C.D. Smyth, Benjamin A. Plog, Jonathan Kipnis

Institution: Washington University in St. Louis

Language: English

Topic: Cerebrospinal fluid and hydrocephalus

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030