Work

Outcomes and Microbiological Characteristics of Adult Patients with Chemotherapy-Induced Febrile Neutropenia Admitted at a Tertiary Hospital in Kenya

Year: 2025

Type: article

Abstract: water samples, 447 (40.2%) were index GNBs predominantly E.coli.Carbapemen and colistin resistance was observed in 100% and 13% of Acinetobacter isolates, respectively.Carbapenemase genes NDM/OXA 48 alone or co expression in 78.5% of GNB from humans & 20% from animal and 3% fish isolates.Discussion: Overall, most of the index GNBs were multidrug resistant across multihost species although the frequency was high in humans and colistin & carbapenem resistance being more prevalent in humans and nil in animals.Geospatial analysis revealed overlapping antibiotic resistance pattern for the index GNB from different hosts sharing the common geography/environment.Conclusion: This one-health framework analysis is critical for understanding the antibiotic resistance profile and transmission dynamics across the hosts.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2024.107680

Authors: Dr Abhijit Ghose, Dr Felix Riunga, Dr Jasmit Shah, RN Charles Makasa

Institution: Aga Khan University Hospital

Language: English

Topic: Neutropenia and Cancer Infections

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900