Insights into the burden of bacterial antimicrobial resistance (AMR) in the WHO Eastern Mediterranean Region: a crucial step towards evidence-informed and targeted public health interventions
Year: 2025
Type: article
Abstract: study, A. baumannii predominated, with 80% being MDR organisms.Polymicrobial and fungal BSIs occurred later during hospitalization, highlighting evolving infection patterns in burn patients.Since both gram-positive and gram-negative infections occurred early in the admission, with polymicrobial infections more common later, initial targeted narrow-spectrum antimicrobial use is not possible.Instead, antimicrobial de-escalation should be prioritized once culture results are available.Additionally, infection prevention protocols and proper wound care should be strictly adhered to, to reduce BSIs.Conclusion: Our findings emphasise the need to shift focus from treating BSIs to preventing them through wound care and infection control.Broad-spectrum antibiotics should be used judiciously and quickly de-escalated to minimise AMR development.
Authors: Dr. Tomislav Mestrovic, Dr Gisela Robles Aguilar, Mr Lucien R Swetschinski, Mrs Nicole Davis Weaver, Mrs Eve E Wool, Mrs Authia P Gray, Prof Kevin S Ikuta, Mr Chieh Han, Mrs Anna Gershberg Hayoon, Prof Erin Chung, Prof Simon I Hay, Prof Christiane Dolecek, Prof Benn Sartorius, Prof Christopher J L Murray, Prof Mohsen Naghavi
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W4408046393