Group B Streptococcus genomic epidemiology indicates that the neonatal disease-associated clonal complex 23 is the major lineage found colonizing pregnant women in Brazil
Year: 2025
Type: article
Abstract: Results: Genome of E. coli 1455 strain harbored a circular chromosome and two plasmids of 167.740-bp and 4.073-bp in length, respectively.E. coli 1455 belonged to the ST3, serotype O17:H18 and carried different determinants including resistance to B-lactams, tetracyclines, and quinolones.In addition, genome of E. coli 1455 strain harbored 5 integrated pro-phage regions mainly located in the chromosome, while most of the virulence factors associated to the invasiveness and clinical severity and different antimicrobial resistance determinants (blaTEM-1, tet(A) and qnrS1) were located in the 167-Kb plasmid. Conclusion:In conclusion, here we characterized the virulence factors in a E. coli causing meningitis in a newborn and provide a deeply picture of the genomic structure related to the disease severity.Taken together, our findings suggest a possible widespread of a virulence factors-carrying plasmid worldwide and highlight the importance of genomic characterization in the diffusion of public health threats.
Authors: Dr Laura Oliveira, Dr Natalia Costa, MSc Leandro Simões, Dr Penelope Marinho, Dr Sérgio Fracalanzza, Dr Lucia Teixeira, Dr Uzma Khan, Dr Dorota Jamrozy, Dr Stephen Bentley, Dr Tatiana Pinto
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W4408046530