Work

Diagnostic Value of Molecular Detection of Treponema pallidum DNA for Diagnosis of Early Infectious Syphilis and Neurosyphilis in an Irish Tertiary-Care Hospital

Year: 2025

Type: article

Abstract: the detection of NTM was low ( < 90%) but high ( ≥90%) for the detection of MTBC.In patients with a positive auramine O smear microscopy result, alternative diagnostic methods like molecular assays that can reliably detect and distinguish between MTBC and NTM in clinical samples should be considered while awaiting mycobacterial culture results.A negative auramine O smear microscopy result may be used to rule out the presence of MTBC but not NTM. Conclusion:The diagnostic utility of auramine O smear microscopy for detecting NTM and MTBC in clinical samples is limited by its poor sensitivity and PPV.These findings highlight the need for more accurate and reliable diagnostic techniques for detecting NTM and MTBC directly from clinical samples.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2024.107553

Authors: Dr Aneesa Solwa, Dr Brendan Crowley, Ms Yvonne Lynagh, Ms Blair Delaney

Institution: St. James's Hospital

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900