Work

Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics?

Year: 2025

Type: article

Abstract: the detection of NTM was low ( < 90%) but high ( ≥90%) for the detection of MTBC.In patients with a positive auramine O smear microscopy result, alternative diagnostic methods like molecular assays that can reliably detect and distinguish between MTBC and NTM in clinical samples should be considered while awaiting mycobacterial culture results.A negative auramine O smear microscopy result may be used to rule out the presence of MTBC but not NTM. Conclusion:The diagnostic utility of auramine O smear microscopy for detecting NTM and MTBC in clinical samples is limited by its poor sensitivity and PPV.These findings highlight the need for more accurate and reliable diagnostic techniques for detecting NTM and MTBC directly from clinical samples.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2024.107554

Authors: Dr Alex Howard, Dr Charlotte Brookfield, Dr Conor Rosato, Dr Anoop Velluva, Dr Alessandro Gerada, Professor William Hope

Institution: St. James's Hospital

Language: English

Topic: Mycobacterium research and diagnosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900