Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: In this study, we first characterized systemic hypercapnia and headache severity during graded CO2 exposures (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO2). Using a randomized, double-blind, crossover trial, we then showed that prophylactic treatment with 400 mg caffeine mitigates systemic hypercapnia and headache during graded CO2 exposure. Overall, these novel findings establish caffeine as the first evidence-based countermeasure to mitigate adverse effects associated with CO2 exposure.
Source: Journal of Applied Physiology
Authors: Benjamin J. Ryan, Thomas A. Mayer, Billie K. Alba, Karleigh E. Bradbury, Shaun C. Brazelton, Nisha Charkoudian, K. Riley Connor, Benjamin A. Fry, Gabrielle E. W. Giersch, Rachel A. Gioscia-Ryan, Andrew M. Greenfield, Harris R. Lieberman, Afton D. Seeley, John H. Sellers, Joseph D. Shevchik, Jesse A. Stein, Erik R. Swenson, Roy M. Salgado
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4408052907