Work

Euphraticanoids N–T: Aromadendrane-Type Diterpenes and Sesquiterpenes with Fungicidal Activities from Populus euphratica Resins

Year: 2025

Type: article

Abstract: Seven previously undescribed terpenoids, including five prenylaromadendrane-type diterpenes euphraticanoids N–R (1–5) and two aromadendrane-type sesquiterpenes, euphraticanoids S and T (6 and 7), were isolated from Populus euphratica resins. Their structures, including their absolute configurations, were elucidated by HRESIMS and spectroscopic analysis, ECD calculations, and crystallographic methods. In addition, an evaluation of the fungicidal activities of compound 1 was carried out, resulting in the discovery of 1 as a fungicidal candidate lead compound with an EC50 of 15.7 and 68.6 mg/L against Curvularia mebaldsii and Fusarium graminearum, respectively.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms26052187

Authors: Qinbin Jiang, Yun-Yun Liu, Danling Huang, Yong-Xian Cheng

Institutions: Shenzhen University, Guangdong Pharmaceutical University

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,499

Funder: Shenzhen Fundamental Research Program