Work

Synthesis, characterization, molecular docking, ADME study, and antimicrobial evaluation of new fenamate-isatin hybrids

Year: 2025

Type: article

Abstract: Molecular hybridization produced six new derivatives by combining isatin analogues with two fenamic acid derivatives. These compounds were characterized using FT-IR and 1 H-NMR and tested for antimicrobial activity. Most of these compounds show potent activity compared to ciprofloxacin against gram-positive bacteria ( Staphylococcus aureus , Streptococcus pneumoniae , and Bacillus subtilis ) and gram-negative ( Neisseria gonorrheae , Pseudomonas aeruginosa , and Escherichia coli ). Additionally, they demonstrated a higher antifungal activity than fluconazole against Candida albicans . A molecular docking study was performed for all six hybrids with three proteins: E. coli DNA Gyrase B (PDB: 6H86), S. aureus (PDB: 2W9H), and CYP51 (PDB: 4WMZ). The results showed promising inhibition of the bacterial and fungal proteins. Furthermore, the ADME study predicted favorable drug-like properties for these compounds.

Source: Pharmacia

DOI: 10.3897/pharmacia.72.e143889

Authors: Lubna Layth Taha, May Mohammed Jawad Al-Mudhafar

Institutions: Ministry of Health, University of Baghdad

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107