Work

Catalyst-Controlled Regiodivergent Oxidation of Unsymmetrical Diols

Year: 2025

Type: article

Abstract: In this work we use aminoxyl-peptide conjugates to catalyze the regiodivergent oxidation of unsymmetrical diols. Through structural tuning of both the aminoxyl catalytic core and the chiral peptide backbone, we achieved catalyst control that either reinforces or overrides the intrinsic steric bias, leading to oxidation of either the less hindered or the more hindered alcohol in high selectivity.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c00330

Authors: Samson B. Zacate, Jonas Rein, Soren D. Rozema, Reginald A. Annor, Scott J. Miller, Song Lin

Institutions: Cornell University, Yale University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green