Complete Remission with Nivolumab Monotherapy of Advanced Gastric Neuroendocrine Carcinoma
Year: 2025
Type: article
Study design: Case Report
Abstract: A 77-year-old man with large-cell gastric neuroendocrine carcinoma underwent palliative total gastrectomy after 10 cycles of carboplatin and etoposide chemotherapy for severe tumor bleeding. Despite a histological grade 0 therapeutic effect, the remnant lesions were treated with paclitaxel and ramucirumab, but progression occurred after two cycles. Nivolumab monotherapy was then initiated, resulting in complete remission after three cycles. Nivolumab was discontinued because of immune-related psoriasis, but complete remission persisted for at least 16 months. This is the first reported case of nivolumab monotherapy achieving complete remission in gastric neuroendocrine carcinoma with the patient surviving 28 months.
Source: Internal Medicine
Authors: Koichiro Tajima, Yuichi Shimodate, Hirokazu Mouri, Yoshio Nagahisa, Shinichi Nishina, Motowo Mizuno
Institution: Kurashiki Central Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408056901