Recent Advances on Asymmetric Synthesis of Dihydroflavones
Year: 2025
Type: article
Abstract: Dihydroflavones, as an important part of flavonoid compounds, possess a wide range of physiological activities and significant medicinal values. The importance of these compounds has driven the research on the preparation of dihydroflavonoid compounds, and many chiral dihydroflavonoid compounds can be obtained with potential activity, excellent yields, and stereoselectivity using various effective synthetic strategies. This paper reviews the biological activities of single-configuration chiral flavanones and provides a comprehensive overview of the research progress in the asymmetric synthesis of this group of flavonoids from 2002 to 2024, including (1) synthesis from ortho-hydroxy chalcones, (2) synthesis from chromones, (3) asymmetric reduction, (4) intramolecular Mitsunobu and carbene insertion. These methods provide some efficient and economical synthetic strategies for the asymmetric synthesis of flavanones, especially in enantioenriched aspects.
Source: Pharmaceutical Fronts
DOI: 10.1055/a-2510-4827
Authors: Zhihao Du, Guojing Li, Wenhao Dai, Yu Liu
Institution: Shanghai Institute of Pharmaceutical Industry
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408059008