Lobectomy for Papillary Thyroid Carcinoma With Minimal Extrathyroidal Extension: Does the Site of Extension Matter?
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: There is limited data on the recurrence risk following lobectomy in patients with microscopic extrathyroidal extension (mETE) and the significance of the site of mETE. METHODS: A retrospective study on patients treated with thyroid lobectomy between January 2012 and December 2023. RESULTS: Sixty-seven patients with papillary thyroid carcinoma (PTC) and mETE were included. Two patients (4.66%) experienced disease recurrence during a mean follow-up of 50 months (IQR 18.8-70.3). Twenty-five patients (37.3%) had anterior extension, 28 (41.8%) posterior, and 14 (20.9%) unknown location. Tumors with posterior extension had a higher rate of tall-cell variant (23.1% vs. 12%) and fewer positive surgical margins (22.2% vs. 37.5%). Three non-disease-related deaths occurred during follow-up. No recurrences were noted in patients with anterior mETE. CONCLUSION: The recurrence risk after hemithyroidectomy for PTC with mETE was 4.66%, consistent with low-risk disease. Posterior mETE demonstrated a trend of a more aggressive variant and a higher recurrence rate.
Source: Head & Neck
DOI: 10.1002/hed.28113
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4408070179