Cytotoxic Lesions of the Corpus Callosum (CLOCCs) in a Patient with Epstein–Barr Infection: A Case Report and Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: Background Cytotoxic lession of the corpus callosum ( CLOCCs) is a rare disorder of various etiologies that is referred as the transient lesion of splenium of the corpus callosum with usually mild clinical course. Epstein-Barr virus (EBV) is a one of factors potentially responsible for triggering this abnormality. Case raport: The authors present a case of a 15-year-old girl, so far without any health burden, who suffered from severe CLOCCs, with the etiology of EBV. The patient was admitted to hospital because of hepatosplenomegaly and hypertransaminasemia. Her condition rapidly deteriorated – she had seizures with respiratory failure, needed treatment in PICU. The first MRI (Magnetic resonance imaging) scan showed changes in the hippocampus, in the early control - changes of the nature of CLOCCs; in follow-up studies ( one and three months after the onset of respiratory failure) gradual incomplete regression of changes in the corpus callosum was seen. Clinical condition improved quickly, no seizures during follow-up, no signs of focal CNS deficits Cases of CLOCCs are reported as secondary syndrome connected with many disease en-tities( toxic, infectious, metabolic). Clinical presentation is a spectrum from asymptomatic cases to severe , demanding intensive treatment. The diagnosis is set by MR examination. Conclu-sions: . General prognosis for CLOCCs is good, though normalization of brain MRI can take even several months. MRI being the only method to show CLOCCs has become an imaging gold standard. Still, clinical abnormalities often precede radiological changes, as happened in reported patient.
Source: Brain Sciences
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,654
OpenAlex ID: W4408071552