Work

Fluorescent half-salen phenoxy-imine zinc complexes to reveal exogenous and endogenous H2S

Year: 2025

Type: article

Abstract: In this contribution, the synthesis and the reactivity with HS − of a family of half-salen Zn complexes are reported. We provide evidence that HS − binds the zinc center of all the complexes under investigation. DFT and CCSD(T) calculations were performed to model the reactivity of these complexes with HS − . We successfully applied a homoleptic zinc complex bearing a Schiff-based ligand with pyridine pendant arms as a probe for the monitoring of exogenous and endogenous H 2 S levels in live cells. We studied the reactivity of HS − with a family of fluorescent zinc complexes. Interaction with HS − results in its coordination to the Zn center for all the complexes under investigation. Bio-imaging experiments indicated the potential in using this class of compounds for the detection of H 2 S in living cells. • Fluorescent Zn complexes as HS − sensors • Detection of endogenous and exogenous H 2 S • Detection of H 2 S produced by UV-C irradiated HepG2 cells.

Source: Journal of Inorganic Biochemistry

DOI: 10.1016/j.jinorgbio.2025.112875