Antimicrobial activity of extracts of Murraya paniculata on bacteria isolated from patients with oral cavity infection
Year: 2024
Type: article
Abstract: InformationOral diseases like dental caries and periodontal diseases have become important health challenges worldwide.This study was carried out on the effects of leaves and bark extracts of Murraya paniculata on identified bacterial strains from the oral cavity of patients with oral infection.The microorganisms isolated were Chryseobacterium meningosepticum, Ochrobactrum anthropi, Moellerella wisconsensis, Eikenella corrodens and Chromobacterium violaceum and the antibacterial activities of methanolic, hot water and cold water extracts of the Murraya paniculata leaves and bark on these microorganisms were observed.The methanolic extract of the leaves had zones of inhibition within the range of 17-32 mm, while the hot water and cold water extracts had none.The methanolic, hot water and cold water extracts of the plant bark had no inhibitory effect on the isolates.The extracts of both the leaves and bark of the plant were compared with the antibacterial effects of commercially available toothpastes (CUP, CUH, DHO, DHM, CFC, CFT and NCH), which showed that some of the toothpastes (CUP and CFC) had inhibitory effect on the isolates within the range of 14-21mm while others (CUH, DHM, DHO, CFT and NCH) had none.The antibiotic susceptibility test carried out showed that the isolates were susceptible to some antibiotics; ofloxacin, gentamycin and levofloxacin and resistant to others like cefuroxime, ampiclox, cefotaxime, imipenem/cilastatin, nalidixic acid, amoxicillin/clavulanate.The gas chromatographymass spectrophotometry (GC-MS) analysis of the Murraya paniculata leaves extract revealed seventeen active compounds, while the Murraya paniculata bark extract, showed twenty-two compounds.This study revealed that the methanolic extract of the plant leaves was potent against the tested isolates.These antimicrobial activities may be attributed to the presence of active compounds in the extracts, which could be incorporated into conventional toothpastes.
Institution: Bells University of Technology
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4408077674