Work

Abrocitinib for treatment of solid facial edema

Year: 2025

Type: article

Abstract: Solid facial edema (SFE), or Morbihan syndrome, is a rare, disfiguring, and difficult-to-treat condition characterized by the gradual onset of erythema and solid edema affecting the upper portion of the face.1,2 It is considered a complication or late-stage manifestation of rosacea or acne. The involvement of perilymphatic granulomas has been suspected in the pathogenesis of SFE,3,4 and Janus kinase (JAK) inhibitors have recently shown efficacy in treating cutaneous granulomatous diseases.5 We report the cases of 3 patients with SFE who demonstrated substantial improvement after treatment with abrocitinib (JAK 1 inhibitor).

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2025.02.001

Authors: Axel De Greef, Marie Baeck

Institutions: Cliniques Universitaires Saint-Luc, UCLouvain

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750