Investigating of the physico-chemistry thiolated dextran derivatives
Year: 2025
Type: article
Abstract: The study aimed to create redox-responsive dextran carriers for controlled hydrophobic molecule release using glutathione, a natural cellular reducing agent, by modifying dextran with a thiol derivative. Investigating the impact of different hydrophobic length on the molecular self-organization of polysaccharide derivatives into nanoparticles helped to understand their roles in this process. The study demonstrated that thiolated dextran particles can be used as emulsifier and can effectively encapsulated hydrophobic molecules like Nile red dye, with the disulfide linkage being cleaved by glutathione under physiological conditions for rapid release. Additionally, the dextran-based particles were found to be non-toxic to living cells. • Design of thiolated dextran with different length of hydrophobic chain • Development of redox-responsive particles based on dextran derivative • Hydrophobic loading and controlled release • Emulsifying property of dextran derivative
Authors: Cléa Chesneau, Andréa Pelletier, Angélique Goffin, Loren Jørgensen, Madara Dias Wickramanayaka, Alexandre Hinzpeter, Sabrina Belbekhouche
Institutions: Centre National de la Recherche Scientifique, Université Paris-Est Créteil, Institut de Chimie et des Matériaux Paris-Est, Laboratoire Eau, Environnement et Systèmes Urbains, Université Paris Sciences et Lettres, Sorbonne Université, Sciences et Ingénierie de la Matière Molle, ESPCI Paris, Inserm, Université Paris Cité, Institut Necker Enfants Malades
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
Funder: Agence Nationale de la Recherche
OpenAlex ID: W4408080079