Human Papillomavirus in Jordan—A selective study of 650 cases
Year: 2025
Type: article
Study design: Observational Study
Abstract: • 25.7% frequency of HPV was found in 650 residents of Amman, Jordan. • Peak incidence of HPV in Jordanian women occurred at later period than in western peers. • Like in many other countries, HPV 16 was the commonest genotype in Jordan. • 5 % of 98 Jordanian women carrying HR-HPV showed abnormal cervical smears. • Sero-conversion to negative developed in 36% of HPV carriers after 2.8-year follow up. To study occurrence of Human papillomavirus (HPV) in the community of Amman, Jordan through analyzing 650 samples randomly referred from community-based gynecology clinics during the years 2011-2023. Findings, including follow-up cases, were compared with those reported from within and outside this region. This study used Liquid Based Cytology (LBC) technique. Samples from gynecology clinics underwent HPV genotyping by RT-PCR machine, then a Consultant Pathologist reported on corresponding ThinPrep slides. Positive cases were stratified into High or Low Risk (HR-HPV or LR-HPV) genotypes, if infection is single, multiple or mixed HR-HPV with LR-HPV. Numbers, age distribution and peak incidence of HPV in an Amman community were analyzed. 644 females and 6 males (husbands) resident in Amman, all from gynecology clinics, showed HPV infection in 152/591(25.7%) natives Group I , and 19/59 (23.2%) expatriates Group II. Group I showed106 single, 38 double, 7 triple and one quadruple infection; 114/152 (75%) were HR-HPV; 15 (9.9%) were mixed HR and LR-HPV. Group II showed 15 single, 3 double and one triple infection; 15/59 (79%) in Group II were HR-HPV, 3 (15.8%) mixed and one LR-HPV. Most frequent genotypes were 16 and 11 for HR-HPV and LR-HPV respectively. Incidence of HPV occurred during 30-44 years in Jordanians and 25-49 years in expatriates. Abnormal cervical smears with high and low grade neoplasia were seen in association with HR-HPV genotypes. HPV converted to negative in 22/61 (36%) average follow-up (FU) 2.8-years and to positive in 4 (6.6%), 1.2-year average FU. A selective study limited to Amman, Jordan indicates that cervical HPV, particularly HR-HPV infection, exerts impact on residents of Amman, Jordan, in whom cervical cancer ranks 10 th in women 15-44 years old. Any extrapolation on incidence rates awaits extension into other cities and rural zones of Jordan. Occurrence of HR-HPV genotypes and follow up data justify promoting HPV vaccination programs to curb cervical cancer.
Source: IJID Regions
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,380
OpenAlex ID: W4408107597