Work

Evaluating the efficacy of doripenem against Staphylococcus aureus in vancomycin-resistant strains

Year: 2025

Type: article

Abstract: Determination of antibiotic susceptibility is a crucial aspect of antimicrobial therapy . The objective of this study was to determine the specific susceptibility of Staphylococcus aureus (SA) to the antibiotic doripenem . A total of 180 clinical isolates from VRSA patients were tested against doripenem using minimum inhibitory concentration (MIC) and disk diffusion tests . The overall findings indicated that doripenem exhibited a high sensitivity level for SA isolates, with an MIC 50 of 60 μg/mL and a MIC90 of 0.5 mg/mL. Additionally, the antimicrobial activity of doripenem, both alone and in combination with amoxiclav against VRSA showed consistent biofilm inhibition within 48 and 24 h, respectively. Furthermore, these results demonstrate that doripenem maintains its high efficacy against VRSA and the combination of amoxiclav with doripenem presents a potential option for managing these resistant infections.

Source: Microbial Pathogenesis

DOI: 10.1016/j.micpath.2025.107449

Authors: Boosan Balaji B, Pitchiah Sivaperumal, Dhanraj Ganapathy, Kannan Kamala

Institution: Saveetha University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,140