Work

A meta-analytic evaluation of cognitive endophenotypes for attention-deficit/hyperactivity disorder: Comparisons of unaffected relatives and controls.

Year: 2025

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: = 0.20). There were no significant differences between unaffected first-degree relatives and non-ADHD controls on measures of inhibition, arousal, motor functioning, planning, and delay aversion. Substantial heterogeneity in effect sizes was explained by differences in samples but with limited evidence of moderation by sex and age. Overall, these findings suggest that nonexecutive cognitive domains along with working memory and cognitive flexibility may be most fruitful for linking genetic risk for ADHD to other causal factors and ultimately to the expression and continuation of ADHD symptoms. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Source: Journal of Psychopathology and Clinical Science

DOI: 10.1037/abn0000985

Authors: Leiana de la Paz, Brendan M. Whitney, Ethan M. Weires, Molly A. Nikolas

Institution: University of Iowa

Language: English

Topic: Attention Deficit Hyperactivity Disorder

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Iowa, National Institute of General Medical Sciences