Work

Primary tibial bone involvement in Rosai Dorfman Disease treated with surgery and radiotherapy; case report and literature review

Year: 2025

Type: article

Abstract: Rosai-Dorfman disease is a rare benign disease that is characterized by over-production and accumulation of white blood cells, known as (histiocytes) in the lymph nodes (nodal) or any other areas of the body (extranodal). It usually presents as painless, massive cervical lymphadenopathy. Extranodal disease involvement is also common but isolated primary involvement of bone is rare. We present a case of isolated primary tibial bone involvement in Rosai-Dorfman disease as the only presentation. It was treated with surgery in the form of curettage and bone cementing with adjuvant radiotherapy. Five years of follow-up did not show any recurrence or disease dissemination.

Source: Journal of Orthopaedic Reports

DOI: 10.1016/j.jorep.2025.100612

Authors: Abdullah F. Alotaibi, Talal Alrawaf, Osama Alshaya, Hassan Sawan, Muath Aljufayr

Institution: King Fahd Medical City

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600