Work

Metagenomic next-generation sequencing identifies native valve Aspergillus fumigatus endocarditis with cerebral involvement: a case report

Year: 2025

Type: article

Abstract: Aspergillus endocarditis is a rare but highly fatal condition, particularly in immunocompromised patients. This case report describes a 74-year-old male with native valve Aspergillus fumigatus endocarditis and intracranial infection. Diagnosis was complicated by atypical presentation and negative blood cultures, but metagenomic next-generation sequencing (mNGS) enabled rapid identification of the pathogen. This case is notable for being the first to document Aspergillus fumigatus endocarditis with cerebral involvement confirmed by mNGS, highlighting the importance of early diagnosis and advanced diagnostic tools in improving outcomes.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1487543

Authors: Weibing Wu, Jingjing Xu, Jianling Ruan, Baoping Tian, Nanxia Xuan

Institutions: Second Affiliated Hospital of Zhejiang University, Lishui City People's Hospital, Zhejiang University

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801