Multifaceted, unique role of CD11c in leukocyte biology
Year: 2025
Type: review
Abstract: CD11c is widely known as a dendritic cell surface marker but its non-dendritic cell expression profiles as well as its functional role have been gradually delineated. As a member of leukocyte-specific β2 integrin family, CD11c forms a heterodimer with CD18. CD11c/CD18 takes different conformations, which dictate its ligand binding. Here we reviewed CD11c current state of art, in comparison to its sister proteins CD11a, CD11b, and CD11d, illustrating its unique feature in leukocyte biology.
Source: Frontiers in Immunology
Authors: Lifei Hou, Sophia Koutsogiannaki, Koichi Yuki
Institutions: Boston Children's Hospital, Harvard University
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408137073