3D Printing with tuneable degradation: Thiol-ene and thiol-yne containing formulations for biomedical applications
Year: 2025
Type: article
Abstract: • Introduced thiol-ene, thiol-yne systems for degradable 3D printing formulations. • 3D printing precision with novel photo-curable resin systems. • Achieved tuneable degradation rates suitable for biomedical implants. • Optimised mechanical and thermal properties for patient-specific applications. • Demonstrated shape memory capabilities. Despite advances in the range of materials that can be used in 3D printing and their applications across numerous scientific disciplines, the controlled breakdown of their solid structures after printing remains challenging. In this study we report the development of tuneable degradable 3D printed formulations, that could be 3D printed using standard digital light processing (DLP) and then degraded as required under mild conditions. Thirteen thiol-ene and thiol-yne formulations were designed to provide a range of tailored mechanical properties, with controlled degradation rates, and specific thermal behaviours with potential relevance to biomedical applications. The formulations ranged from ones with high stiffness for structural applications, through to those capable of rapid degradation. These formulations demonstrate full degradability and stability in physiological conditions, showing potential for future drug delivery applications pending further toxicity and release studies. This balance of degradability and mechanical robustness offers significant potential for enhancing patient safety and reducing the invasiveness of surgical treatments as directed by clinical needs.
Authors: A. Locks, B.J. Bowles, S. Brown, H.C. Hailes, S.T. Hilton
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
OpenAlex ID: W4408140621