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Association of serum magnesium level with small fiber neuropathy in patients with type 2 diabetes

Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose We aimed to investigate the association between serum magnesium (Mg) levels and small fiber neuropathy among patients with type 2 diabetes mellitus (T2DM). Methods This study retrospectively collected data from patients with T2DM. Patients were divided based on the quartiles of the serum concentrations of Mg. Corneal confocal microscopy (CCM) was employed to determine the morphological parameters of corneal nerve fibers, including corneal nerve fiber length (CNFL), fiber density (CNFD), and branch density (CNBD). Pearson correlation analysis and multiple linear regression analyses were conducted to investigate the association between the serum levels of Mg and the morphological parameters of corneal nerve fibers. Results In total, 136 patients with T2DM were enrolled in this study. All morphological parameters of corneal nerve fibers increased with the increasing quartiles of serum Mg levels. Using Pearson correlation analysis, we found a significant and positive association between the serum levels of Mg and CNFL (r = 0.550, p < 0.001), CNFD (r = 0.432, p < 0.001), and CNBD (r = 0.425, p < 0.001). After adjusting for covariates, the serum levels of Mg remained positively correlated with CNFL (β = 0.495, p < 0.001), CNFD (β = 0.361, p < 0.001), and CNBD (β = 0.374, p < 0.001) in the fully adjusted model. Conclusion The serum levels of Mg were positively and independently correlated with the morphological parameters of the corneal nerve among patients with T2DM. Serum Mg levels can serve as a potential biomarker for screening corneal small fiber neuropathy in patients with T2DM.
DOI: 10.3389/fmed.2025.1509820
Authors: Xiaoting Liu, Jianzhang Hu
Language: English
Field: Nursing
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408149080
FWCI: 0.551
Cites: 46
Cited by: 1
Related to: 10