Work

Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy

Year: 2025

Type: article

Abstract: The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of noncanonical antigens with single amino acid substitutions resulting from translational errors. These peptides, shared across patients with PDAC, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC. See related article by Zhang et al., p. 1956.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-24-4368

Authors: Hao Yuan, Qun Chen, Kuirong Jiang, Courtney W. Houchen, Yuqing Zhang, Min Li

Institutions: University of Oklahoma Health Sciences Center, Jiangsu Province Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: William and Ella Owens Medical Research Foundation, National Cancer Institute