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Symmetrical Peripheral Gangrene in an Indian Child with Severe Scrub Typhus

Year: 2025

Type: article

Abstract: Scrub typhus is one of the common causes for acute febrile illness in monsoon and post-monsoon season in our region. It usually presents as fever, rash, and thrombocytopenia with or without multiorgan dysfunction syndrome (MODS). Infrequently, it can cause focal or symmetrical peripheral gangrene (SPG). Here, we report a 5-year-old female who presented with acute febrile illness with MODS and SPG in bilateral lower limbs. The diagnosis of scrub typhus was confirmed with positive scrub typhus IgM antibodies. She recovered completely after combination therapy with doxycycline and azithromycin, and organ supportive therapy (mechanical ventilation, vasoactive drugs, and continuous renal replacement therapy) in the pediatric intensive care unit.

Source: American Journal of Tropical Medicine and Hygiene

DOI: 10.4269/ajtmh.24-0801

Authors: Prasanna Samynathan, Neha Sharma, Priyanka Meena, Manisha Biswal, Suresh Kumar Angurana

Institution: Post Graduate Institute of Medical Education and Research

Language: English

Topic: Vector-borne infectious diseases

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408150472