Work

Successful Management of Lupus‐Associated Autoimmune Myelofibrosis with Tofacitinib: A Case Report

Year: 2025

Type: article

Abstract: We report a case of a 34-year-old woman with systemic lupus erythematosus (SLE) who developed thrombocytopenia and was diagnosed with lupus-associated autoimmune myelofibrosis. She was treated with hydroxychloroquine, tofacitinib (5 mg twice daily), intravenous Ig, and prednisone (5 mg twice daily, tapered to 5 mg daily after one month). After 10 months of this regimen, her bone marrow showed complete resolution of myelofibrosis. This case highlights the effectiveness of tofacitinib in the treatment of autoimmune myelofibrosis associated with SLE.

Source: ACR Open Rheumatology

DOI: 10.1002/acr2.70017

Authors: Hamidreza Soltani, Ali Dehghan

Institution: Shahid Sadoughi University of Medical Sciences and Health Services

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,550