Year: 2025
Type: article
Study design: Case Report
Abstract: A 73-year-old male presented with an abnormal chest x-ray revealing ground-glass opacity (GGO) in the left lower lung field, accompanied by elevated KL-6, SP-D, and GM-CSF antibody levels, indicative of autoimmune pulmonary alveolar proteinosis (PAP). Initial bronchoalveolar lavage and transbronchial lung biopsy revealed only nonspecific findings. During a CT-guided needle aspiration biopsy (CT-NAB), real-time imaging showed that GGO gradually moved and shifted with positional changes. Although PAP is not fully confirmed yet due to a lack of pathological findings, this case highlights several clinical suggestions for patients with atypical lung shadows, including those with suspicion of PAP. Further, this is the first report of lung shadow mobility during CT-NAB, emphasising the need for further studies to elucidate the pathophysiology of lung shadows and improve diagnostic accuracy.
Source: Respirology Case Reports
DOI: 10.1002/rcr2.70139
Authors: Tomohiro Bando, Yumiko Sasaki, Wataru Koike, Kazuko Watanabe, Tadayoshi Hirano, Soei Gen, Mitsuaki Yagi, Daizo Yaguchi, Masato Shizu, Motoshi Ichikawa
Institution: Gifu Prefectural Tajimi Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,130
OpenAlex ID: W4408161955