Core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition disease: OMERACT delphi survey to establish consensus
Year: 2025
Type: article
Abstract: OBJECTIVE: To agree on important domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition (CPPD) disease. METHODS: Patient research partners (PRPs) and other participants (mainly clinicians and researchers) contributed to three rounds of a consensus survey using Delphi methodology. Consensus was defined if ≥70% of both patients and other participants scored the domain as 'critically important domain to include'. In a subsequent ranking exercise, all participants were asked to select and rank up to 10 of the domains reaching consensus. RESULTS: Fifteen domains reached consensus as critically important. Within the Pathophysiological Manifestations area, these were joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, joint damage on imaging tests, joint calcification on imaging tests, and crystals in joint fluid. Within the Life Impact area, these were overall function, ability to complete daily tasks, ability to work, health related quality of life, patient global assessment response to treatment, patient global assessment of disease activity, physician global assessment of disease activity, and patient satisfaction with treatment. No domains within the Societal/Resource Use area reached consensus as critically important. In the ranking exercise, joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare and overall function were most highly ranked. CONCLUSION: This work has identified potential domains for the OMERACT core domain set for chronic and/or recurrent manifestations of CPPD disease. There was strong support for joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, overall function, and global assessments of disease activity as core domains.
Authors: Yiling Zhang, Sara K. Tedeschi, Abhishek Abhishek, Owen Hensey, David Grossberg, Ken Cai, Beverley Shea, Jasvinder A. Singh, Robin Christensen, Teodora Serban, Edoardo Cipolletta, Konstantinos Parperis, Cesar Diaz-Torne, Geraldine M McCarthy, Fabio Becce, Tamer A Gheita, Silvia Sirotti, Sara Nysom Christiansen, Luis Coronel, Lisa K Stamp, Yousra H Abdel-Fattah, Tristan Pascart, Georgios Filippou, Lih En Hong, John FitzGerald, Nicola Dalbeth
Institutions: University of Auckland, Brigham and Women's Hospital, University of Nottingham, Nottingham Biomedical Research Centre, OMERACT Patient Research Partner Network, Westmead Hospital, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, University of Southern Denmark, Frederiksberg Hospital, Odense University Hospital, Bispebjerg Hospital, Marche Polytechnic University, University of Cyprus, Hospital de Sant Pau, University College Dublin, Centre Hospitalier Universitaire Vaudois, Cairo University, IRCCS Ospedale Galeazzi - Sant'Ambrogio, Vall d'Hebron Hospital Universitari, University of Otago, Alexandria University, Université Catholique de Lille, University of Milan, Royal Adelaide Hospital, University of California, Los Angeles
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,370
Funder: Arthritis New Zealand
OpenAlex ID: W4408174976