Work

Fluorescent polymer nanoparticles for targeted drug delivery and synergistic osteosarcoma therapy

Year: 2025

Type: article

Abstract: Osteosarcoma (OS) is a malignant bone tumor that predominantly affects adolescents, with symptoms including localized pain and swelling. DKK1 , an antagonist of the Wnt signaling pathway, plays a pivotal role in tumor progression. This study presents a novel fluorescent nanocarrier ( PLA-PEG-RhB ) designed for the targeted delivery and controlled release of a therapeutic combination of compound 1 and doxorubicin (DOX) (CP1@1@DOX). The PLA-PEG-RhB carrier, composed of rhodamine B , PLA , and PEG , enhances drug bioavailability and targeting while enabling real-time fluorescence tracking. The synergistic effect of compound 1 and DOX within the nanocarrier significantly inhibits osteosarcoma cell proliferation and reduces tumor growth, minimizing toxicity to healthy cells. In vitro, PLA-PEG-RhB@CP1@ 1 @DOX suppressed osteosarcoma cell proliferation by regulating DKK1 expression and blocking key tumor progression pathways. This study highlights the potential of fluorescent nanomedicine combined with targeted chemotherapy for osteosarcoma treatment.

Source: Journal of the Indian Chemical Society

DOI: 10.1016/j.jics.2025.101660

Authors: Yunfei Lin, Bing Wang

Institution: Peking University First Hospital

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,600