Work

Colorectal liver metastasis resection results in excellent long-term quality of life and low symptom burden

Year: 2025

Type: article

Abstract: INTRODUCTION: Prognostic factors in patients who undergo liver resection for colorectal liver metastases (CRLM) have been investigated, but limited research exists on health-related quality of life (HRQoL), functional status, and ongoing symptoms. This study aimed to assess the long-term HRQoL of life and examine the factors associated with HRQoL, functional status, and ongoing symptoms. MATERIALS AND METHODS: This was a cross-sectional study of patients who had curative resection between 2010 and June 2021. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 (a generic questionnaire) and QLQ-LMC21 (CRLM-specific) questionnaires. RESULTS: In total, 121 patients underwent liver resection, of which 85 were alive. There was a 61 % response rate (n = 52). The median postoperative time when the survey was completed was 4.0 years (1-13.1). Overall, most patients were doing well, with a median global HRQoL score of 83 and scores >80 in all domains. Most symptoms were assigned a median score of "0". There were no clinical factors that significantly impacted HRQoL and only trivial differences in relation to physical symptoms. CONCLUSION: This study demonstrates excellent long-term HRQoL and functional status in patients who undergo liver resection for CRLM and have long-term survival.

Source: European Journal of Surgical Oncology

DOI: 10.1016/j.ejso.2025.109751

Authors: Nazim Bhimani, Mbathio Dieng, Patrick J. Kelly, Thomas J. Hugh

Institutions: The University of Sydney, Royal North Shore Hospital

Language: English

Topic: Cancer survivorship and care

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,810