A New Antibacterial Diterpene with a Fused 6-5-6-6 Ring System, Trichodermanin I, Isolated from the Soil-Derived Fungus Trichoderma atroviride YD-13
Year: 2025
Type: article
Abstract: One new diterpene with a fused 6-5-6-6 ring system, trichodermanin I (1), along with three known ones, wickerols A and B and trichodermanin F (2-4), were acquired from the extract of Trichoderma atroviride YD-13 isolated from soil. Their chemical structures were determined by interpretation of 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Compound 1 was evaluated for inhibiting the growth of four human pathogenic bacteria (Clostridium botulinum, Escherichia coli, Salmonella, and Staphylococcus aureus) and exhibited potential antibacterial activity against C. botulinum, E. coli, and S. aureus with MIC values of 8.0 μg/mL, 32 μg/mL, and 16 μg/mL, respectively.
Source: Records of Natural Products
Authors: Liang Hong, Rui Chen, Linsa Zhou, Jie Lin
Institution: Ruian People's Hospital
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408185727