A Case Report on Cerebral Venous Sinus Thrombosis With Factor V Leiden Mutation in the Postpartum Period
Year: 2025
Type: article
Study design: Case Report
Abstract: Cerebral venous sinus thrombosis (CVST) remains an elusive diagnosis in the pregnancy and postpartum periods requiring heightened clinical vigilance due to its potential for severe morbidity and mortality, including seizures, strokes, and death. This neurologic emergency typically responds well to anticoagulation therapy, though some cases may require endovascular interventions like thrombectomy. Here, we describe the case of a 28-year-old female patient who was two weeks postpartum at the time of presentation and had a history of migraines responsive to over-the-counter medication, presenting with persistent headaches unresponsive to typical analgesics which she typically uses for her migraines. She was diagnosed with CVST, which was further complicated by a heterozygous factor V Leiden mutation. The patient exhibited a favorable response to anticoagulation treatment.
Source: Cureus
DOI: 10.7759/cureus.80158
Authors: Oluwasegun A Shoewu, Jevon Harrison, Auda H Auda, Juan Escobar, Monica Liriano, Iyad Baker
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408186529