Work

Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland

Year: 2025

Type: article

Abstract: The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.

Source: European Journal of Clinical Microbiology & Infectious Diseases

DOI: 10.1007/s10096-025-05093-w

Authors: Abdessalam Cherkaoui, Patrice Francois, Nadia Gaia, Gesuele Renzi, Adrien Fischer, Jacques Schrenzel

Institutions: University of Geneva, University Hospital of Geneva

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,890