Work

Synthesis and study of antifungal activity of aromatic aldehyde 1,3-thiazol-2-yl hydrazones

Year: 2024

Type: article

Abstract: A number of 1,3-thiazol-2-yl hydrazones of aromatic aldehydes were synthesized and tested for antifungal activity. It was found two promising compounds: 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine has MIC of 8 μg/ml against Cryptococcus neoformans and MIC of 16 μg/ml against Candida albicans and 4-[(1Z)-{2-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazin-1-ylidene}methyl]-2,6-dimethoxy-phenol has MIC of 0.5 μg/ml against Cryptococcus neoformans, respectively

Source: Ukrainica Bioorganica Acta

DOI: 10.15407/bioorganica2024.02.037

Authors: Sergiy S. Tarnavskiy, Sergiy S. Lukashov, Volodymyr G. Bdzhola, Volodymyr V. Voitiuk, Sergiy M. Yarmoluk

Institution: Institute of Molecular Biology and Genetics

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Wellcome Trust, University of Queensland, National Academy of Sciences of Ukraine

Awards: G137004906, G623078255