Work

Preliminary evaluation of the effect of partially hydrogenated 3-acetylisocoumarin derivatives on the cancer cells growth

Year: 2024

Type: article

Abstract: In different conditions, from 3-acetyl-1H-isochromen-1-one three partial reduction products were obtained, namely 3-(1-hydroxyethyl)-1H-isochromen-1-one, 3-(1-hydroxyethyl)isochroman-1-one, and 3-ethylisochroman-1-one. The influence of two products with an alcohol fragment, as well as 4-hydroxy-1,2,3,4-tetrahydro-6H-benzo[c]chromen-6-one, on the growth of cancer cells was investigated through One Doses Full NCI 60 Cell Panel Assay. The only one significant effect was found: 3-(1-hydroxyethyl)-1H-isochromen-1-one practically stops the growth of CCRF-CEM cell lines (Leukemia)

Source: Ukrainica Bioorganica Acta

DOI: 10.15407/bioorganica2024.02.033

Authors: Oleh V. Shablykin, Olga V. Shablykina, Ilona Yu. Tarasiuk

Institutions: Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar, Taras Shevchenko National University of Kyiv

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Enamine, National Cancer Institute