Work

Chemoenzymatic method for the synthesis of enantiomerically pure fluorine-substituted β-methylphenylethylamines

Year: 2024

Type: article

Abstract: A synthetic approach has been developed leading to the synthesis of new building blocks – enantiomerically pure fluorine-substituted β-methylphenylethylamines. A methodology of kinetic dynamic enzymatic resolution was employed at key stages. A dual enzymatic purification method was applied to achieve a high degree of optical purity of the obtained products. The resulting amines are promising building blocks for developing new pharmaceuticals and physiologically active compounds

Source: Ukrainica Bioorganica Acta

DOI: 10.15407/bioorganica2024.02.003

Authors: Anastasiia O. Kolodiazhna, Oleh O. Faiziiev, Olga O. Kolodiazhna

Institution: Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Enamine

OpenAlex ID: W4408193246

FWCI:

Cites: 24

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Related to: 10