Inflammasomes in lymphocytes as therapeutic targets
Year: 2025
Type: article
Abstract: • Inflammasomes are cytoplasmic macromolecular complexes that play a critical role in the function of lymphocytes, including T, B and NK cells. • Dysregulation of inflammasome expression contributes to the progression of various diseases. • Investigating inflammasomes in lymphocytes may provide novel therapeutic strategies for their modulation. Inflammasomes are cytoplasmic macromolecular complexes playing an important role in sensing exogenous and endogenous stimuli. Inflammasome activation leads to IL-1β and IL-18 secretion and pyroptosis. The concept of non-self recognition triggering inflammasome activation has been well-established for myeloid cells. However, increasing evidence suggests the presence of functional inflammasome or inflammasome-related components in lymphocytes. Dysregulated expression of inflammasome contributes to the development of many diseases, including cardiovascular, infectious, neurodegenerative diseases and cancer. Multiple clinical trials are being conducted to assess drugs targeting various inflammasome components. This review discusses current knowledge on inflammasome activation in T, B and NK cells and explores their potential as therapeutic targets. Further understanding inflammasome and pyroptotic pathways in lymphocytes may have implications in the development of novel immunotherapeutic strategies.
Source: Translational Oncology
Author: Zarema Albakova
Institution: Lomonosov Moscow State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
OpenAlex ID: W4408200027