Year: 2024
Type: article
Abstract: Tablets can be subdivided by patients for several reasons.However, these subdivisions are not guaranteed to produce acceptable splits using the known subdivision techniques.The main objective of this study is to evaluate the use of bilayer tablets to obtain suitable tablet subdivisions.Bilayer tablets of two formulations were evaluated.The bilayer tablets were produced by compaction of 250 mg of powder at 43 MPa followed by compaction of an additional 250 mg of the same powder at 43 MPa.Each of the evaluated bilayer tablets was either composed of microcrystalline cellulose (MCC) or a mixture of MCC and caffeine.Subdivisions were performed by pressing the metal tip of a lancet on the edge of the bilayer tablet at the interface between the layers.Properties of the bilayer tablets and the subdivided layers were determined.Furthermore, the friability of the bilayer tablets was tested.It was found that the produced bilayer tablets lost less than 1% of their weight and did not delaminate during the friability test.Moreover, it was found that two almost intact tablets were subdivided from each bilayer tablet.The weight of each subdivision was close to 50% of the weight of the whole bilayer tablet.The standard deviations of the percentage weights of the subdivisions were less than or equal to 0.15%.Therefore, it was possible to subdivide bilayer tablets to produce tablet splits with relatively high accuracy and precision. RezumatObiectivul principal al acestui studiu a fost de a evalua utilizarea comprimatelor bistratificate pentru a obține subdiviziuni adecvate.Au fost evaluate tablete bistrat din două formulări farmaceutice.Tabletele cu două straturi au fost produse prin compactarea a 250 mg de pulbere la 43 MPa urmată de compactarea a încă 250 mg din aceeași pulbere la 43 MPa.Fiecare dintre comprimatele cu două straturi evaluate a fost compus fie din celuloză microcristalină (MCC), fie dintr-un amestec de MCC și cafeină.Subdiviziunile au fost efectuate prin apăsarea vârfului metalic al lancetei pe marginea tabletei, la interfața dintre straturi.Au fost determinate atât proprietățile comprimatelor bi-strat cât și ale straturilor subdivizate.În urma determinării friabilității, s-a concluzionat că aceste comprimate bistratificate obținute au pierdut mai puțin de 1% din greutate și nu s-au delaminat.Greutatea fiecărei subdiviziuni a fost aproape de 50% din greutatea întregului comprimat.Abaterile standard ale ponderilor procentuale ale subdiviziunilor au fost mai mici sau egale cu 0,15%.
Source: FARMACIA
Author: SHADI GHARAIBEH
Institution: Jerash University
Language: English
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408200359