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Assessment of Hepatoprotective Potential of Dendrobium bicameratum, a Bryophyte from Eastern Ghats, Odisha

Year: 2025

Type: article

Abstract: An investigation was conducted to assess the hepatoprotective potential of hydroalcoholic andaqueous extracts of Dendrobium bicameratum in Wistar rats with carbon tetrachloride (CCl4)-induced hepaticdamage. The extent of liver injury was evaluated by measuring serum biomarkers, including SGOT, SGPT,total albumin, total protein, IL-1β, IL-6, and TNF-α. Administration of hydroalcoholic (HADBM) and aqueous(ADBM) extracts at 200 mg/kg, as well as silymarin (100 mg/kg), demonstrated significant (P < 0.05)hepatoprotective effects by reducing the levels of serum hepatoprotective and inflammatory mediators. Thesefindings suggest that Dendrobium bicameratum extracts exhibit pronounced hepatic protection, comparableto the standard hepatoprotective agent silymarin.

Source: Cuestiones de Fisioterapia

DOI: 10.48047/9emmpf45

Authors: Bishnu Prasad Sahu, Manish Kumar Gautam, Biplab Kumar Dey, Bibekananda Meher

Institution: Assam Down Town University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4408202170

FWCI: 0.88

Cites:

Cited by: 1

Related to: 10