Work

Supramolecular Partners: Precision On/Off Neuromuscular Blockage for Prolonged Surgeries

Year: 2025

Type: article

Abstract: The development of a long-acting neuromuscular blocking agent and its on-demand reversal is highly desired for prolonged surgeries. This viewpoint discussed the discovery of supramolecular partners, an imidazolium-based macrocycle (YW70271) and acyclic cucurbit[n]uril (WY22051), for ultralong neuromuscular blockade and rapid reversal.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00557

Authors: Ziyi Wang, Hang Yin, Ruibing Wang

Institution: University of Macau

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500