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The Relationship Between Gene Mutations and Prognosis in Patients With Stage I Non-small Cell Lung Cancer After Surgery

Year: 2025

Type: article

Abstract: This article discusses the relationship between gene mutations and prognosis in patients with stage I non-small cell lung cancer (NSCLC) after radical surgery. The study highlights that EGFR and ALK mutations are common in Stage I NSCLC patients and significantly affect both disease-free survival (DFS) and overall survival (OS). Patients with EGFR mutations respond well to EGFR-TKI treatment, significantly prolonging DFS; similarly, ALK mutation patients show improved prognosis with ALK inhibitor treatment. In contrast, patients with KRAS mutations have poorer outcomes, with common treatments including chemotherapy and immunotherapy. The importance of genetic testing in comprehensive postoperative treatment for early-stage NSCLC is highlighted, suggesting that individualized adjuvant therapy may play a role in improving long-term prognosis.

Source: Journal of Pharmaceutical and Medical Research

DOI: 10.61784/jpmr3029

Authors: Rui Ouyang, Ming Du

Institution: The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4408206650

FWCI:

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